MỘT SỐ ĐẶC ĐIỂM DỊCH TỄ HỌC LÂM SÀNG BỆNH LUPUS BAN ĐỎ HỆ THỐNG Ở TRẺ EM TẠI BỆNH VIỆN NHI TRUNG ƯƠNG

Abstract

Objectives: To describe clinical and subclinical characteristics of systemic lupus erythematosus in children. Subjects and research methods: cross-sectional description on 107 pediatric patients diagnosed with lupus erythematosus at the National Children's Hospital. Results: Boys accounted for 14.1% and female patients accounted for 85.9%. Common clinical signs were kidney damage (100%) of cases, skin and mucosal lesions (71%) and arthritis (50.5%). The rate of anemia patients on admission was 77.6% and 74.8% of pediatric patients had a change in white blood cell count. The proportion of patients with decreased C3 complement concentration was 82.2% and decreased C4 concentration was 81.3%. There were 82.2% cases with positive anti-DNA antibodies and 59.8% cases with positive antinuclear antibodies. According to SLEDAI criteria: there were no patients with inactivity, 0.9% of cases with mild activity, 8.4% of cases with moderate activity and 72% with high activity and 18.7% of cases. compounds with very high activity. Conclusion: the common clinical symptoms are kidney damage, skin and mucous membrane damage, arthritis. Most patients have decreased levels of complement C3 and C4 and are positive for anti-DNA antibodies. Most cases were highly active according to the SLEDAI criteria.