SẢN XUẤT THUỐC BẰNG CÔNG NGHỆ IN 3D FDM PHẦN 1: NGUYÊN LÝ VÀ QUY TRÌNH HOẠT ĐỘNG

Abstract

3 dimension (3D) printing was utilized, for the first time, as a manufacturing platform for fabrication of pharmaceutical dosage forms in 2000 [1]. However, not until the first approval of Spritam by US. FDA in 2015, application of 3D printing in pharmaceutical sciences gained its growing interest. The technology is involving in the layer-by-layer deposition of materials to fabricate 3 dimension objects according to a digital model. The American Society for Testing and Materials (ASTM) classified 3D printing technology into 7 categories, namely material extrusion, material jetting, powder bed fusion, binder jetting, vat photopolymerisation, sheet lamination and directed energy deposition. 3D fused deposition modelling (FDM), a material extrusion based technique, is the most researched technique owing to its simple, low cost and highly flexibility. FDM allows to fabricate various dosage forms with highly complex geometries that offer a great potential to customize drug release profiles. This paper reviewed systematically the technical fundamental, requirements, step by step procedure and critical parameters of a 3D FDM process.