Article Sidebar

PDF
Date Published: 04/08/2021
Abstract Views: 466
Views PDF: 205
DOI: https://doi.org/10.51298/vmj.v503i2.803
Issue
Vol. 503 No. 2 (2021)
Section
Các bài báo
How to Cite
Thị Hải Dương, V. ., Minh Tuấn, V. ., & Trung Hà, P. . (2021). CORRELATION BETWEEN SERUM IRON, FERRITIN LEVELS AND RISK OF GESTATIONAL DIABETES MELLITUS. Vietnam Medical Journal, 503(2). https://doi.org/10.51298/vmj.v503i2.803

CORRELATION BETWEEN SERUM IRON, FERRITIN LEVELS AND RISK OF GESTATIONAL DIABETES MELLITUS

Võ Thị Hải Dương, Võ Minh Tuấn, Phạm Trung Hà

Main Article Content

Abstract

Background: Iron is one of the micronutrients that necessary for cellular functions to ensure the normal development of the fetus. However, in addition to the positive effects, iron overload in the body causes oxidative stress, which can lead to insulin resistance, as well as reduce function of pancreatic β cells. This becomes a double-edged sword in pregnancy. Objective: The aim of the study was to determine the relationship between serum iron and ferritin levels with GDM. Methods: A case control study (ratio 1:2) was conducted with 192 pregnant women from 24 to 28 weeks of gestation who have antenatal care at SaiGon International OB-GYN Hospital, from December 2020 to April 2021 (64 pregnant women with GDM as cases & 128 pregnant women without GDM as controls according to diagnostic criteria of the American Diabetes Association, 2018). Venous blood samples in 75-g 2-hour oral glucose tolerance test were used for estimation of serum iron and ferritin. Result: Group with serum ferritin levels ≥ 30 ng/mL increased the risk of gestational diabetes to 5,04 (OR*= 2,01; KTC 95%: 1,71 – 14,79), p < 0,05. Conclusion: There was no association found between iron serum levels and GDM, but high ferritin level was associated with an increased risk of GDM.

Article Details

Keywords

gestational diabetes mellitus, serum iron levels, ferritin levels, 75-g 2-hour oral glucose tolerance test

References

1. American Diabetes Association (2018). "Classification and Diagnosis of Diabetes: Standards of Medical Care in Diabetes-2018", Diabetes Care, 41 (1), pp. S13-S27.
2. Amiri F N, Basirat Z, et al (2013). "Comparison of the serum iron, ferritin levels and total iron-binding capacity between pregnant women with and without gestational diabetes", J Nat Sci Biol Med, 4 (2), pp. 302-305.
3. Faranak S, Amir Z (2010). "Serum ferritin concentration in gestational diabetes mellitus and risk of subsequent development of early postpartum diabetes mellitus", Diabetes Metab Syndr Obes, 3, pp. 413-419.
4. Kale S D, Kulkarni S, et al (2005). "Characteristics of gestational diabetic mothers and their babies in an Indian diabetes clinic", JAPI, 53, pp. 857-863.
5. Preeti C, Parijat G, et al (2020). "Association of Maternal Serum Ferritin Level in Gestational Diabetes Mellitus and its Effect on Cord Blood Hemoglobin", International Journal of Contemporary Medical Research, 7 (1), pp. A1-A4.
6. Soheilykhah S, Mojibian M, et al (2017). "Serum ferritin concentration in early pregnancy and risk of subsequent development of gestational diabetes: A prospective study", International Journal of Reproductive BioMedicine, 15 (3), pp. 155-160.
7. Wang Z, Fan H B, et al (2018). "Correlation between plasma ferritin level and gestational diabetes mellitus and its impact on fetal macrosomia", Journal Diabetes Investigation, 9 (6), pp. 1354-1359.
8. Zein S, Rachidi S, et al (2015). "High iron level in early pregnancy increased glucose intolerance", J Trace Elem Med Biol, 30, pp. 220-225.