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Date Published: 15/01/2024
Abstract Views: 136
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DOI: https://doi.org/10.51298/vmj.v534i1.8033
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Vol. 534 No. 1 (2024)
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Cấn, X. H. ., & Trần , T. C. . (2024). EFFICACY AND SAFETY OF PACLITAXEL CARBOPLATIN IN THE TREATMENT OF PATIENTS WITH NON-SMALL CELL LUNG CANCER. Vietnam Medical Journal, 534(1). https://doi.org/10.51298/vmj.v534i1.8033

EFFICACY AND SAFETY OF PACLITAXEL CARBOPLATIN IN THE TREATMENT OF PATIENTS WITH NON-SMALL CELL LUNG CANCER

Xuân Hạnh Cấn, Thị Chung Trần

Main Article Content

Abstract

Objectives: To evaluate the results and safety of second-line treatment with Paclitaxel-carboplatin regimen in patients with stage IIIB-IV non-small cell lung cancer. Methods: A cross-sectional descriptive study combining retrospective and prospective with longitudinal follow-up on 42 patients with stage IIIB-IV non-small cell lung cancer receiving second-line paclitaxel-carboplatin regimen at National Lung Hospital. The implementation period is from January 2016 to June 2019. Results: The average age of the patients was 56 ± 3.1, the female/male ratio was 2.5/1, stage IV patients accounted for 66.7%. Overall response rate (ORR) was 42.8%, disease control rate (DCR) was 83.3%. Progression-free survival 2 (PFS2) had a median value of 6.4 months (range 3.1 – 10.1 months). In the course of treatment, the patient had good tolerance, mild toxicity (grade 1, 2) and was uncommon in the hematopoietic and non-haematopoietic systems. Conclusion: Patients with stage IIIB-IV NSCLC who received second-step treatment with paclitaxel-carboplatin chemotherapy regimen had a high overall response rate and disease control rate, prolonged progression-free survival, acceptable safety.

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References

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