NGHIÊN CỨU ĐỘC TÍNH CẤP VÀ ĐỘC TÍNH BÁN TRƯỜNG DIỄN CỦA VIÊN NÉN STONEBYE TRÊN THỰC NGHIỆM

Abstract

Objective: This study was carried out evaluate the acute and subchronic toxicity of STONEBYE tablets on experimental animals. Methods: The study acute toxicity was conducted on white mice as per WHO guidelines. Assessment study of the subchronic toxicity was performed on white rats administered STONEBYE tablets at the doses of 0.48 tables/kg b.w./day and 1.44 tables/kg b.w./day orally in 90 consecutive days. Results: STONEBYE tablets at the dose of 45 tablets/kg b.w. (46.87 times of predicted human dose) did not cause the acute toxicity and the LD₅₀ on white mice had not been determined. The STONEBYE tablets at the doses of 0.48 tables/kg b.w./day and 1.44 tables/kg b.w./day administered orally in 90 consecutive days did not affect the white rats’ general state, weight, hematologic levels, kidney and liver functions and histopathological images. Conclusion: STONEBYE tablets’ acute and subchronic toxicity had not been determined on experimental animals.