ĐẶC ĐIỂM LÂM SÀNG, CẬN LÂM SÀNG VÀ TÍNH NHẠY CẢM KHÁNG SINH CỦA KLEBSIELLA PNEUMONIAE GÂY NHIỄM KHUẨN HUYẾT TẠI CỘNG ĐỒNG

Abstract

Objectives: Describe the clinical, laboratory characteristics and antibiotic susceptibilities of patients with community-acquired sepsis due to Klebsiella pneumoniae treated at the National Hospital of Tropical Diseases from 2018 to 2023. Participants and Methods: A cross-sectional descriptive study involving 102 patients diagnosed with sepsis caused by K. pneumoniae. Results: The average age of the patients studied was 54.82 ± 12.8 years old. Common underlying conditions included diabetes (46.1%), cirrhosis (29.4%), and hypertension (25.5%). All patients had fever, the nature of the fever was usually chills (68.6%). Commonly infected organs are digestive symstem (59.8%), respiratory symstem (29.4%) and central nervous symstem (29.6%). Regular blood tests upon hospitalization showed thrombocytopenia (< 150 G/L) in 61.8% of cases, with an average leukocyte count of 12.7 ± 6.3 G/L. Coagulation disorders were observed in patients. 61.8% of cases increase total bilirubin > 17 µmol/L, 75.3% decrease albumin < 35 g/L, increase AST and ALT in over 70% of cases. Creatinine ≥ 120 µmol/L in 13.9% of patients. Most of patients increased infectious indices at high levels, CRP > 100 mg/L (78.0%) and PCT > 10 ng/ml (50.9%). We recorded an increase in drug resistance of K. pneumoniae in the study, especially, 7% of cases were resistant to carbapenem compared to previous studies. Conclusion: Community-acquired sepsis due to K. pneumoniae predominantly affects individuals elderly with underlying health conditions, leading to multi-organ dysfunction. The prevalence of antibiotic-resistant K. pneumoniae in the community is on the rise.