KẾT QUẢ THAI KỲ Ở NHỮNG THAI PHỤ ĐƯỢC TIÊM PHÒNG VACXIN COVID-19 SINH TẠI BỆNH VIỆN PHỤ SẢN TRUNG ƯƠNG

Abstract

Objective: Review of pregnancy outcomes in pregnant women vaccinated with COVID-19 vaccine who delivery at the National Hospital of Obstetrics and Gynecology. Methods: A cross-sectional descriptive study on 340 pregnant women vaccinated with COVID-19 vaccine druring pregnancy who delivery at ethe National Hospital of Obstetrics and Gynecology from September 2021 to September 2022. Results: A total of 340 pregnant women participated in this study, 340 (100%) vaccinated with Pfizer, 295 (86,8%) received the 2-dose vaccination, 36 (10,6%) received the 1-dose vaccination, 9 received the 3-dose vaccination; all vaccinations occurred during second or third trimesters. The most common side effect was pain, swelling, redness and warmth at the injection site (40,2%). The cesarean rate, preterm birth rate, COVID-19 incedence, prevalence of small for gestational age were 49,4%, 4,1%, 7,9%, 7,0%, respectively. When comparing the number of vaccine doses or the time period received vaccine, no difference were found between the groups in pregnancy outcomes, except vaccinations occurred during second trimesters increased the COVID-19 incedence in infants less than 6 months of age compared to vaccinations occurred during third trimesters, (the first dose: OR=1,864, 95%CI: 1,198 – 2,902; the last dose: OR=2,627, 95%CI: 1,603 – 4,304); and increased the prevalence of small for gestational age (OR=2,534, 95%CI: 1,014 – 6,333). Conclusion: COVID-19 vaccination administered during pregnancy is not linked to significant adverse events regardless the number of vaccine doses or the time periof received vaccine. Vaccinations occurred during third trimesters may reduce the incedence COVID-19 in infants less than 6 months and the prevalence of small for gestational age.