ĐẶC ĐIỂM CỦA HỘI CHỨNG CHỒNG LẤP TRONG XƠ CỨNG BÌ TẠI BỆNH VIỆN ĐẠI HỌC Y DƯỢC THÀNH PHỐ HỒ CHÍ MINH

Abstract

Introduction: Overlap syndrome is a condition in which a patient has features that meet the diagnostic criteria for at least two connective tissue diseases. Overlap syndrome in systemic sclerosis has different characteristics, which can affect the disease progression, prognosis, treatment and outcome of the patient. Data on this disease is still limited, so we conducted this study. Material and methods: A cross-sectional, descriptive study with 83 SSc patients visited the Rheumatology Clinic – University Medical Center HCMC from January 2023 to September 2023. Patients who met the diagnostic criteria for SSc and other connective tissue diseases according to ACR/EULAR had their clinical and subclinical characteristics recorded. Results: 18/83 SSc patients had overlap syndrome. The most common overlap diseases are systemic lupus erythematosus and rheumatoid arthritis. The mean age in the overlap syndrome group was lower than the SSc group. Arthritis is a typical symptom more common in the overlap syndrome group (77.78%). Raynaud's phenomenon is less common in overlap syndrome. Lower white blood cell counts and frequent anti-Ro52 autoantibodies are laboratory features of the overlap syndrome. Conclusions: Overlap syndrome can be seen in 21.68% of scleroderma patients. The most common overlapping diseases are systemic lupus erythematosus and rheumatoid arthritis. Young age, arthritis, rarely Raynaud's phenomenon, low white blood cells and anti-Ro52 autoantibody are features that can be seen in overlap syndrome.