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RESULTS OF CETUXIMAB PLUS PLATINUM-BASED CHEMOTHERAPY AS THE FIRST LINE THERAPY OF RECURRENT OR METASTATIC SQUAMOUS-CELL CARCINOMA OF THE HEAD AND NECK
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Abstract
A cross-sectional descriptive prospective and retrospective study evaluated the efficacy of first-line cetuximab plus platinum-based chemotherapy for 27 patients with recurrent or metastatic squamous-cell carcinoma of the head and neck at K Hospital from January 2019 to March 2023. Response rate, progression-free survival (PFS), overall survival (OS), and adverse effects were evaluated. The results showed the response rate was 44.5%; disease control rate was 77.8%. The median FPS was 6.2 months, and the median OS was 12 months. The most common adverse events included rash acneiform, anemia, neutropenia, diarrhea and nausea, vomiting, about 40 -50% at all grade, however, most toxicities were grade 1-2, with fewer cases of grade 3-4 toxicity. In conclusion, cetuximab combined with platinum-based chemotherapy as first-line treatment for recurrent or metastatic squamous-cell carcinoma of the head and neck yielded favorable results with acceptable toxicity, in line with global studies.
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