KẾT QUẢ XÁC ĐỊNH NGUY CƠ UNG THƯ VÚ BẰNG PHẦN MỀM CANRISK

Abstract

Objective: This study aims to evaluate the effectiveness and practical applicability of the CanRisk tool in assessing the risk of breast cancer. Methods: The research involved the retrospective analysis of medical records of 40 individuals who had been diagnosed with breast cancer. The Canrisk tool was utilized to calculate breast cancer risk based on input data, including information about risk factors and genetic mutations  Result: Among the 40 cases of breast cancer confirmed by histopathology, the Canrisk tool identified 7 cases (17.5%) as having a high risk of breast cancer. The remaining cases were categorized as being in the population risk group. In one instance, a familial breast cancer case was identified, wherein the subject and their relatives carried the BRCA1/2 gene mutation. This prompted a recommendation for genetic testing, revealing that all tested individuals with the mutation carried the BRCA1 mutation. Conclusion: The outcomes of this preliminary study demonstrate CanRisk's capacity to forecast the prevalence of BRCA1/2 gene mutations in cases of familial breast cancer in Vietnam. It proves effective in gauging breast cancer risk among individuals carrying BRCA1/2 gene mutations, yet it has not proven to be notably superior to conventional screening methods in all cases.