THE RESULTS OF SURGICAL COMBINED PREORATIVE CHEMOTHERAPY AND POSTOPERATIVE CHEMOTHERAPY IN STAGE IIIC-IV OVARIAN CANCER AT K HOSPITAL
Main Article Content
Abstract
Materials and methods: Prospective combined retrospective descriptip study 58 patients diagnosed with stage IIIC-IV ovarian cancer who received surgical combined preoperative chemotherapy and postoperative chemotherapy at K hospital from 9/2019-10/2023. Results: Overall survival time for the entire study patient population was 34 months (CI 95% 29.3-38.7 months). In which, the survival time of the entire group receiving chemotherapy was 32 months, the survival time of the bevacizumab combination chemotherapy group was 31 months (p = 0.65). The median overall survival time for stage IIIC patients is 31 months, and for stage IV patients is 30 months. There has been no patient death during the follow-up period of pCR. Conclusions: Surgical combined preoperative chemotherapy and postoperative chemotherapy brings good results in treating patients with stage IIIC and IV ovarian cancer.
Article Details
References
2. Nguyễn Thị Thanh Loan, Lê Thanh Đức, Hàn Thị Thanh Bình (2023). Đánh giá kết quả hóa trị tân bổ trợ phác đồ paclitaxel carboplatin trong ung thư buồng trứng giai đoạn III-IV tại bệnh viện K. Tạp Chí Học Việt Nam 530:166–170
3. Vergote I, Tropé CG, Amant F, et al (2010) Neoadjuvant chemotherapy or primary surgery in stage IIIC or IV ovarian cancer. N Engl J Med 363:943–953
4. Tewari D, Java JJ, Salani R, Armstrong DK, Markman M, Herzog T, Monk BJ, Chan JK (2015) Long-term survival advantage and prognostic factors associated with intraperitoneal chemotherapy treatment in advanced ovarian cancer: a gynecologic oncology group study. J Clin Oncol Off J Am Soc Clin Oncol 33:1460–1466
5. Prescott LS, Vergote I, Sun CC, Bodurka DC, Coleman RL (2023) Transfusion use and effect on progression-free, overall survival, and quality of life in upfront treatment of advanced epithelial ovarian cancer: evaluation of the European Organization for Research and Treatment EORTC-55971 Cohort. Int J Gynecol Cancer Off J Int Gynecol Cancer Soc 33:1–9
6. Ivantsov AO (2018) Pathological response of ovarian cancer to neoadjuvant chemotherapy. Chin Clin Oncol 7:59–59
7. van Driel WJ, Koole SN, Sikorska K, et al (2018) Hyperthermic Intraperitoneal Chemotherapy in Ovarian Cancer. N Engl J Med 378:230–240
8. Fagotti A, Ferrandina MG, Vizzielli G, et al (2020) Randomized trial of primary debulking surgery versus neoadjuvant chemotherapy for advanced epithelial ovarian cancer (SCORPION-NCT01461850). Int J Gynecol Cancer Off J Int Gynecol Cancer Soc 30:1657–1664