TỶ LỆ TỬ VONG Ở BỆNH NHÂN NGỘ ĐỘC CẤP HÓA CHẤT DIỆT CỎ DIQUAT VÀ CÁC YẾU TỐ LIÊN QUAN

Abstract

Objective: to determine the mortality rate and analyze factors related to fatal outcome in patients with acute diquat poisoning. Methods: the study included 114 patients with acute diquat poisoning treated at Poison Control Center of Bach Mai Hospital from July 2022 to July 2023. Results: The mortality rate in patients with acute diquat poisoning was 63.2%. Mortality was higher in the age group over 50 (>80%). Fever, tachycardia, and rapid breathing were higher in the fatal group. Vomiting, skin redness, abdominal distention, and high PSS scores were associated with increased mortality. Unconsciousness and seizures had a higher risk of fatal (with RR of 2.776 and 1.953). Acute kidney injury increased the risk of death 13.5 times. Metabolic acidosis with increased anion gap (AG) and increased lactate, increased liver enzymes, and leukocytosis were all associated with fatal outcome. Lactate above 2.6; AG above 17.25 were associated with death with an area under the ROC curve (AUC) of 0.91 with a sensitivity of 81.4% and specificity of 87.5%. Blood diquat above 7.155 was associated with death with an AUC of 0.97; Sensitivity was 81.3% and specificity was 100%. Conclusions: the mortality rate in patients with acute diquat poisoning at the Poison Control Center of Bach Mai Hospital was 63.2%. Reported dosage, blood diquat concentration, heart rate, respiratory rate, fever, liver and kidney damage, neurological damage, metabolic acidosis, and increased lactate were all associated with mortality.