CLINICAL, SUBCLINICAL FEATURES AND SHORT-TERM OUTCOMES OF PATIENTS WITH LIVER FAILURE FOLLOWING HEPATECTOMY AT THE ICU DEPARTMENT- K HOSPITAL

Tiến Đức¬ Nguyễn, Thế Anh Phạm, Hữu Kiên Nguyễn, Hoàng Quốc Đặng

Main Article Content

Abstract

Subjects and methods: Prospective cross-sectional description of 45 patients with hepatocellular carcinoma who underwent hepatectomy, were admitted to the Intensive Care Department of K Hospital, and were diagnosed with liver failure after surgery, the period from 03/2023 to 09/2023. Results: The most common age group was over 60 (51.1%). Males comprised 91.1% of the patients, while females comprised 8.9%. A history of hepatitis was present in 91.1% of patients. Preoperative liver function was categorized as Child-Pugh A (5 points) in 82.2% of patients. The average MELD score of the patients in this study was 7.16 ± 1.15. Liver failure after major hepatectomy was the most common diagnosis (82.2%). Pre-operative liver function classification, according to Child-Pugh and MELD score, did not help predict the degree of liver failure after surgery. 75.6% of patients responded well to liver failure treatment regimens, while 24.4% of patients developed severe disease or died, mainly in the group with liver failure level C (severe progression 100%). Infection and pneumonia were the most common complications in patients with postoperative liver failure. Conclusion: Postoperative liver failure is a significant complication that can lead to death after surgery and is difficult to predict preoperatively.

Article Details

References

1. Balzan S, Belghiti J, Farges O, et al (2005), "The “50-50 criteria” on postoperative day 5: an accurate predictor of liver failure and death after hepatectomy", 242 (6), pp. 824.
2. Mullen J T, Ribero D, Reddy S K, et al (2007), "Hepatic insufficiency and mortality in 1,059 noncirrhotic patients undergoing major hepatectomy", 204 (5), pp. 854-862.
3. Ocak I, Topaloğlu S, Acarli K J T J o M S (2020), "Posthepatectomy liver failure", 50 (6), pp. 1491-1503.
4. Rahbari N N, Garden O J, Padbury R, et al (2011), "Posthepatectomy liver failure: a definition and grading by the International Study Group of Liver Surgery (ISGLS)", 149 (5), pp. 713-724.
5. Siu J, McCall J, Connor S J H (2014), "Systematic review of pathophysiological changes following hepatic resection", 16 (5), pp. 407-421.
6. Strasberg S, Belghiti J, Clavien P-A, et al (2000), "The Brisbane 2000 terminology of liver anatomy and resections", 2 (3), pp. 333-339.
7. VIỆT Đ Q (2022), "Giá trị tiên lượng chức năng gan của độ thanh lọc Indocyanine Green trong phẫu thuật cắt gan", Đại học Y Dược Thành phố Hồ Chí Minh, Hồ Chí Minh.
8. Zhang Z-Q, Xiong L, Zhou J-J, et al (2018), "Ability of the ALBI grade to predict posthepatectomy liver failure and long-term survival after liver resection for different BCLC stages of HCC", 16 (1), pp. 1-9.