GIÁ TRỊ TIÊN ĐOÁN KẾT CỤC TIM MẠCH CỦA NON-HIGH-DENSITY CHOLESTEROL Ở BỆNH NHÂN HỘI CHỨNG MẠCH VÀNH CẤP KHÔNG ST CHÊNH LÊN

Abstract

Background: Many analyses have demonstrated the role of non-HDL-C in evaluating cardiovascular disease due to atherosclerosis. Non-HDL-C levels also have a prognostic role for long-term cardiovascular outcomes in patients who have experienced a cardiac event. However, data on the prognostic role of non-HDL-C in cardiovascular outcomes in Vietnam are limited. Objectives: To describe the non-HDL-C concentration characteristics in patients with acute coronary syndrome and evaluate the predictive role of non-HDL-C for long-term cardiovascular outcomes. Materials: We conducted a cross-sectional study with longitudinal follow-up in 220 patients diagnosed with acute coronary syndrome admitted to Cho Ray Hospital. Methods: Descriptive cross-sectional study with longitudinal follow-up. Results: Of the 220 patients included in the study, the mean age was 65.5 ± 11.0 years, and 59.1% were male. The mean non-HDL-C concentration was 146.5 ± 48.7 mg/dL. The percentage of patients with non-HDL-C < 85 mg/dL and < 100 mg/dL was 9.5% and 14.5%, respectively. After 30 months of follow-up, 9.1% of patients died from any cause. The non-HDL-C concentration was able to predict the 30-month mortality outcome with an area under the curve of 0.64 (95% confidence interval: 0.57 – 0.70). At the non-HDL-C cut-off point of 159 mg/dL, the sensitivity was 90%, and the specificity was 36.5% for predicting all-cause mortality. Conclusions: Our study showed that patients with non-ST-elevation acute coronary syndrome had a low rate of achieving the non-HDL-C target. Non-HDL-C concentration was able to predict all-cause mortality at the 30-month time point.