NGUYÊN NHÂN VÀ MỘT SỐ YẾU TỐ LIÊN QUAN Ở TRẺ EM MẮC COVID-19 TỬ VONG TẠI BỆNH VIỆN NHI TRUNG ƯƠNG

Abstract

Introduction: to describe the causes and some factors related to death in children with COVID-19 at the National Children's Hospital. Methods: This retrospective cohort study on 30 patients diagnosed with COVID-19 who died at the Children's COVID-19 Resuscitation Center - National Children's Hospital from December 2021 to May 2022. Results: Of the 1028 case with COVID-19 treated at the Children's COVID-19 Resuscitation Center, 30 patients died with a rate of 2.9%. Median age 7 months old (IQR: 1 day - 159 months old), most common group under 1 year old (56.7%). 60% of patients identified the source of COVID-19 infection. More than half (53.3%) of patients had underlying disease; in which congenital heart disease (16.7%), followed by congenital biliary atresia (10%). 56.7% of patients presented with acute illness ≤3 days. Symptoms Fever, dyspnea, increased ferritin, LDH, D-Dimer were common in this group of patients. All patients were on invasive mechanical ventilation, with 5 patients continuous renal replacement therapy. The most common cause of death was pneumonia- ARDS, acute encephalitis, septic shock accounting for 23.3% respectively; 20% and 20%. Average hospital stay was 10 days (IQR: 1-58 days). Conclusion: In our study, the majority of children with COVID-19 who died had severe comorbidities, children under 12 months of age, presented with acute illness. Common causes of death ARDS pneumonia, acute encephalitis and septic shock