TÌNH HÌNH SỬ DỤNG KHÁNG SINH TRÊN NGƯỜI BỆNH COVID-19 ĐIỀU TRỊ NỘI TRÚ TẠI BỆNH VIỆN NGUYỄN TRI PHƯƠNG

Abstract

Objective: To evaluate antibiotic use of inpatients with COVID-19 at Nguyen Tri Phuong Hospital. Subjects and methods: Cross-sectional study, retrospective medical record of COVID-19 inpatients aged 18 years and older and assigned antibiotics in the period from July to October 2021. Chi-square test and binary logistic regression were used to determine the association between duration of antibiotic use and other variables. Results: Among 127 patients, severe COVID-10 cases accounted for 62.2%. Community-acquired pneumonia accounted for 100.0% and sepsis accounted for 9.4%. 41.7% of patients were tested for microbiology, of which, 40.8% were sampled before using antibiotics. The rate of positive electrocution accounted for 39.5% and there were only 7 cases of antibiogram (23.3%). The most common bacteria are Staphylococcus sp. (30.0%). The most common initial mono-, dual-, and triple- antibiotic therapy were ceftriaxone (50.0%), ceftriaxone + levofloxacin (65.7%), and meropenem + levofloxacin + vancomycin (28.6%). An inappropriate indication of antibiotics accounted for 7.0% and inappropriate antibiotic dose accounted for 11.0%. Patients who did not take concomitant antiretroviral drugs tended to have longer antibiotic therapy (OR = 0.137). Conclusion: The use of antibiotics in COVID-19 inpatients mostly followed treatment guidelines.