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EVALUATING THE EFFECT OF HIGH-FAT DIET FROM LARD ON THE GLYCEMIC INDEX IN MOUSE
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Abstract
Aims: The study was conducted to analyze the effect of high-fat diet from lard on the glycemic index of laboratory mice. Methods: 8-week-old male mice were divided into 02 groups and underwent nutritional interventions for 66 days. One group ate high-fat diet from lard and the control group ate standard diet. Mice were monitored for weight every 2 days and tested for blood glucose at the end of the experiment with glucose tolerance test (GTT) and insulin tolerance test (ITT). Results: The weight of mice fed high fat diet from lard increased significantly compared to the control group with p<0.001 (8.7g). The blood glucose level in normal status of mice fed high-fat diet was higher than that of the control group, however the difference was not statistically significant. Eating high-fat diet from lard caused glucose intolerance, the mices' glycemic tolerance was impaired by eating high-fat diets compared to the control group. Although mice that eat a lot of lard can start to disturb blood glucose tolerance, insulin tolerance remains stable. Conclusion: The results serve as a basis for future studies on evaluating the impact of high-fat diet from lard on the formation and progression of metabolic disorders such as overweight, obesity and type 2 diabetes caused by high-fat diets of animal origin
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Keywords
High-fat diet, lard; mouse; blood glucose level; weight.
References
2. Thanh, V., Nguy cơ gây đột quỵ do mỡ máu tăng cao. https://suckhoedoisong.vn/nguy-co-gay-dot-quy-do-mo-mau-tang-cao-169143640.htm. 2019, Báo Sức khỏe & Đời sống.
3. Estimated Pork Consumption around the World for 2021 and 2022. https://www.pig333.com/ latest_swine_news/ estimated-pork-consumption-around-the-world-for-2021-and-2022_18160/ (accessed on 1 Janaury 2023).
4. Nguyễn Cao Trí, Võ Minh Tuấn, and e. al, Tạo và đánh giá mô hình chuột nhắt trắng (Swiss Albino) béo phì do khẩu phần ăn giàu chất béo Tạp chí Khoa học và Công nghệ, 2019. 39B.
5. Lang, P., et al., Effects of different diets used in diet-induced obesity models on insulin resistance and vascular dysfunction in C57BL/6 mice. Scientific Reports, 2019. 9(1): p. 19556.
6. Power, R.A., J. Parkhill, and T. de Oliveira, Microbial genome-wide association studies: lessons from human GWAS. Nature Reviews Genetics, 2017. 18(1): p. 41-50.
7. Licholai, J.A., et al., Why Do Mice Overeat High-Fat Diets? How High-Fat Diet Alters the Regulation of Daily Caloric Intake in Mice. Obesity, 2018. 26(6): p. 1026-1033.
8. Kless, C., et al., Diet-induced obesity causes metabolic impairment independent of alterations in gut barrier integrity. Mol Nutr Food Res, 2015. 59(5): p. 968-78.