MỐI LIÊN QUAN GIỮA NỒNG ĐỘ PEPSIN TRONG NƯỚC BỌT VỚI ĐẶC ĐIỂM CƠ THẮT THỰC QUẢN DƯỚI TRÊN CÁC BỆNH NHÂN CÓ BIỂU HIỆN TRÀO NGƯỢC

Abstract

Aim: To describe pepsin in saliva by using Peptest and evaluate the relation between pepsin concentrations and lower esophageal sphincter (LES) in patients with gastroesophageal reflux symptoms. Method: A cross-sectional study was conducted in patients with gastroesophageal reflux symptoms at Institute of Gastroenterology and Hepatology from 06/2020 to 03/2023. Pepsin in saliva was detected by Peptest while LES was detected by high – resolution manometry (HRM). Results: 141 patients with average age of 43,1 ± 11,7, male percentage was 42,6%. Regurgitation was the most frequent symptom. The positive rate of Peptest was 89,9% in sample 1 (pepsin concentration was 79,1 ng/ml) and 81,8% in sample 2 (pepsin concentration was 62,6 ng/ml). There was no significant different in pepsin concentration between LES resting pressure baseline/swallow low/normal, IRP4s low/normal, EGJ-CI low/normal, EGJ morphology and IRP4s combined with esophageal motility low/normal (p < 0,05). There was a slight correlation between LES resting pressure when swallowing, IRP4s with pepsin concentrations. Conclusion: The rate of positive Peptest samples and pepsin concentration in saliva in patients with gastroesophageal reflux symptoms were high. There was a weak correlation between LES resting pressure when swallowing or IRP4s, but no correlation between the LES resting pressure baseline or EGJ – CI with the concentration of pepsin in saliva.