MỘT SỐ ĐẶC ĐIỂM NỒNG ĐỘ AFP TRÊN BỆNH NHÂN CẮT GAN DO HCC TẠI BỆNH VIỆN K

Abstract

Objective: Describe some characteristics of AFP levels in patients undergoing liver resection due to HCC at National Cancer Hospital. Research subjects and methods: A retrospective descriptive study on 228 patients undergoing surgery. Hepatectomy due to HCC (with post-operative pathological diagnosis of HCC) included (47 cases of right anterior sectionectomy, 33 cases of right posterior sectionectomy, 38 cases of central hepatectomy and 110 cases of right hepatectomy) at the Department of Hepatobiliary and Pancreatic Surgery - K Hospital from 2019 to 2023. Research results: Male: female ratio: 9.4:1. Average age: 56.1. Types of hepatectomy included 47 anterior segment hepatectomies (20.6%), 33 posterior segment hepatectomies (14.5%), 38 central hepatectomies (16.7%), and 110 right hepatectomies (48.2%).  AFP rate < 20 ng/ml was 77 cases (33.8%), from 20 - 400 ng/ml was 58 cases (25.4%) and over 400 ng/ml was 93 cases (40.8%); 25.4% of AFP was within normal limits in the group of patients with hepatitis B and C. Median AFP was 130.50 ± 4629.60; There was no difference in AFP level between the group with hepatitis B,C and the normal group (p = 0.181). Tumor size was a factor causing increased AFP level (p = 0.01), tumors size ≥ 5 cm having a 2.12 times higher than tumors size < 5 cm with a 95% confidence interval (1.19 - 3.77). There were 77.6% of HBsAg (+) cases and 3.1% of  HCVAb (+) cases. Poorly differentiated HCC in the increased AFP group (33.1%) was higher than that in the normal AFP group (18.2%). Conclusion: There was no difference in AFP level between the group with hepatitis B,C and the normal group. Tumor size was a factor causing increased AFP level. AFP level was not specific for diagnosing HCC. It was necessary to combine other factors, such as imaging and hepatitis, to confirm the HCC diagnosis.