COMPARISION OF EFFECTS ON HEMODYNAMICS, RESPIRATION, AND SOME SIDES EFFECTS OF GRANISETRONE AND ONDASETRONE FOR PREVENTING NAUSEA AND VOMITING IN WOMEN UNDERGOING SPINAL ANESTHESIA FOR CESAREAN SECTION
Main Article Content
Abstract
Objects: To compare of the effects on hemodynamics, respiration, and some sides effects of granisetrone and ondasetrone for preventing nausea and vomiting in women undergoing spinal anesthesia for cesarean section. Methods: RCT study on 100 patients divided into two groups. Group 1: Using Granisetrone 1mg injection before spinal anesthesia. Group 2: Using Ondansetrone 1mg injection before spinal anesthesia. Results: Granisetrone does not affect hemodynamics and respiration or the incidence of sides effects on pregnant women compared to ondasetron. Conclusion: Granisetrone used to prevent nausea and vomiting in women undergoing spinal anesthesia for C-section does not affected the pregnant women’s respiration and hemodynamics, does not cause arrhythmia and does not increase rate or severity of sides effects compared to ondasetrone.
Article Details
Keywords
Granisetrone, Ondansetrone, spinal anesthesia for cesarean section.
References
2. Metaxari, M., et al., Antiemetic prophylaxis in thyroid surgery: a randomized, double-blind comparison of three 5-HT3 agents. J Anesth, 25(3): p. 356-62
3. Hiep VV, Ánh ND, Lam NĐ. Đánh giá hiệu quả dự phòng nôn, buồn nôn của Ondanseton, Dexamethason hoặc Metoclopramide trong và sau mổ lấy thai dưới gây tê tủy sống. Published online 2020:8
4. Aksoy M, Dostbil A, Aksoy AN, Ince I, Bedir Z, Ozmen O. Granisetron or ondansentron to prevent hypotension after spinal anesthesia for elective cesarean delivery: A randomized placebo-controlled trial. Journal of Clinical Anesthesia. 2021;75:110469.
5. S.Farmawy MMR. Effects of intravenous ondansetron and granisetron on hemodynamic changes and motor and sensory blockade induced by spinal anesthesia in parturients undergoing cesarean section. Egyptian Journal of Anaesthesia.29(4):369-374.