Article Sidebar
Views pdf: 52
CORRELATION OF TUMOR SIZE WITH HISTOPATHOLOGICAL FEATURES IN UVEAL MELANOMA
Main Article Content
Abstract
Objectives: To describe histopathologic features of uveal melanoma and evaluate the association between these features and size of the tumors. Methods: A descriptive, cross-sectional study has been conducted on 48 patients with uveal melanoma who were surgically treated and pathologically diagnosed at Vietnam National Eye Hospital from 1/2019 to 9/2023. Results: Among 48 cases of uveal melanoma, the prevalence of medium and large-sized tumor was 75% and 25%, none of them was small-sized. Large-sized tumors were associated with shape, epitheloid cell and rupture of Bruch’s membrane, were not associated with vascular invasion, invasion of optic nerve and extraocular invasion. Conclusions: Tumor size was associated with some unfavorable prognosis factors (shape of the tumor, epitheloid cell and rupture of Bruch’s membrane) in uveal melanoma.
Article Details
Keywords
uveal melanoma, size.
References
2. Diener-West M., Hawkins B.S., Markowitz J.A., et al. (1992). A Review of Mortality From Choroidal Melanoma: II. A Meta-Analysis of 5-Year Mortality Rates Following Enucleation, 1966 Through 1988. Archives of Ophthalmology, 110(2), 245–250.
3. COMS (1998). Histopathologic characteristics of uveal melanomas in eyes enucleated from the collaborative ocular melanoma study COMS report no. 6. American Journal of Ophthalmology, 125(6), 745–766.
4. Americane Joint Committee on Cancer. Cancer Staging Manual. 8th ed. 2017.
5. Cruz P.O., Specht C.S., and McLean I.W. (1990). Lymphocytic infiltration in uveal malignant melanoma. Cancer, 65(1), 112–115.
6. Shields C.L., Kaliki S., Furuta M., et al. (2015). American Joint Committee on Cancer Classification of Uveal Melanoma (Anatomic Stage) Predicts Prognosis in 7731 Patients. Ophthalmology, 122(6), 1180–1186.
7. Liu Y.M., Li Y., Wei W.B., et al. (2015). Clinical Characteristics of 582 Patients with Uveal Melanoma in China. PLoS One, 10(12), e0144562.
8. Bùi Đào Quân. Đặc điểm lâm sàng và mô bệnh học của u hắc tố ác tính màng bồ đào. Tạp chí nghiên cứu y học. 2021; 137(1), 222-226.
9. Shields C.L., Furuta M., Thangappan A., et al. (2009). Metastasis of Uveal Melanoma Millimeter-by-Millimeter in 8033 Consecutive Eyes. Archives of Ophthalmology, 127(8), 989–998.
10. Pach J.M., Robertson D.M., Taney B.S., et al. (1986). Prognostic factors in choroidal and ciliary body melanomas with extrascleral extension. Am J