SỰ BỘC LỘ PROTEIN P16 VÀ MỐI LIÊN QUAN VỚI ĐẶC ĐIỂM GIẢI PHẪU BỆNH TRONG UNG THƯ BIỂU MÔ TUYẾN DẠ DÀY

Abstract

Purpose: Determine the status of p16 marker expression and its relationship with pathological features of gastric adenocarcinoma according to WHO 2019. Methods: A cross-sectional description on 96 patients diagnosed with gastric ADC at Bach Mai Hospital. Results: The brown-yellow staining of nucleus and cytoplasm is considered positive. P16 staining over 10% was considered positive (+) and staining under 10% as negative (-). Regarding p16 expression in 96 patients with gastric ADC, 54,2% showed positive and 45,8% showed negative. Loss of p16 expression is significantly associated with tumour size (p=0,019), tumour budding grade (p=0,023), lymphatic-vascular invasion (p=0,006), neural invasion (p= 0,03) and lympho nodes metastasis (p=0,018). There is no correlation between p16 expression and tumour location (p=0,458), macroscopic type (p=0,137), WHO histological type (p=0,468), Lauren’s type (p=0,073), depth of invasion (p= 0,122) and metastasis (p=0,33). Conclusion: P16 could be used as a prognostic marker and a diagnostic marker in many kinds of cancer. Loss of p16 expression is usually because of hypermethylation of p16INK4a promoter region. Loss of p16  were strongly correlated with development of gastric cancer. Our research indicate that p16 has a strong association with tumour size, tumour budding grade, lymphatic-vascular invasion, neural invasion and lympho node metastasis. Loss of expression of p16  is considered as a bad risk factor in gastric ADC.