XÁC ĐỊNH HÀM LƯỢNG CHẤT BẢO QUẢN METHYLPARABEN VÀ PROPYL PARABEN BẰNG PHƯƠNG PHÁP SẮC KÝ LỎNG HIỆU NĂNG CAO (HPLC) CÓ TRONG MỘT SỐ MỸ PHẨM LƯU HÀNH TRÊN ĐỊA BÀN THÀNH PHỐ VINH NĂM 2023

Abstract

Paraben is the common name of a group of chemical preservatives, commonly used for a long time. Parabens are slightly soluble in water, soluble in methanol, ethanol and other organic solvents. Sensitivity has occurred when drugs containing parabens were applied to damaged or chapped skin and many other dangerous side effects. In order to determine whether the content of methylparaben and propylparaben mentioned above in cosmetic products is within the allowable limit, we conducted research with the following goals: Qualitative and quantitative determination of methylparaben (MP) and propylparaben (PP) ) using high performance liquid chromatography (HPLC) in a number of cosmetic products (facial cleanser, lotion, skin whitening, skin regeneration, melasma treatment, acne treatment,...) in circulation in Vinh city. Research subjects and methods: 6 cosmetic samples collected in Vinh City in 2023. Determination of parabens using HPLC method. Results: Through surveying the optimal conditions of the method such as: linear range, repeatability, reproducibility, recovery efficiency, we evaluate the research method as completely suitable for application in analysis. cosmetic samples. All 6 analyzed samples were determined to contain methyl paraben and propyl paraben. Conclusion. This result more or less shows that there are parabens in cosmetics, a potential risk to users' health from cosmetic products currently circulating on the market.