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Date Published: 05/02/2024
Abstract Views: 331
Views PDF: 476
DOI: https://doi.org/10.51298/vmj.v535i1.8547
Issue
Vol. 535 No. 1 (2024)
Section
Các bài báo
How to Cite
Nguyễn , V. T. ., Trần, H. T. ., & Hà, T. H. (2024). INTRAVENOUS LIPID 20% EMULSION THERAPY IN THE TREATMENT OF ACUTE POISONING. Vietnam Medical Journal, 535(1). https://doi.org/10.51298/vmj.v535i1.8547

INTRAVENOUS LIPID 20% EMULSION THERAPY IN THE TREATMENT OF ACUTE POISONING

Văn Thực Nguyễn , Hữu Thông Trần, Trần Hưng Hà

Main Article Content

Abstract

Objective: to assess the use of 20% intravenous lipid emulsion (ILE) therapy in the treatment of acute poisoning. Subjects and methods: an observational study included 34 patients with acute poisoning who used ILE from January 2022 to August 2023 at the Poison Control Center of Bach Mai Hospital. Results: ILE therapy was indicated for poisoning of anesthetics, calcium channel blockers, antidepressants and pesticides poisoning; The severity according to PSS: moderate accounted for 29.4%, severe 67.6%, and fatal 2.9%. Indications of ILE were mainly hypotension (38.2%), unconsciousness (29.4%) and cardiac arrest 2.9%. 67.6% of ILE were used immediately in combination with other treatments, 26.5% were salvage therapy. 52.9% of ILE used the correct dose according to the regimen. Conclusion: the study showed the current status of using 20% intravenous lipid emulsion therapy in the treatment of acute poisoning patients at the Poison Control Center of Bach Mai Hospital.

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References

1. Weinberg, G.L., et al., Pretreatment or resuscitation with a lipid infusion shifts the dose-response to bupivacaine-induced asystole in rats. The Journal of the American Society of Anesthesiologists, 1998. 88(4): p. 1071-1075.
2. Rosenblatt, M.A., et al., Successful use of a 20% lipid emulsion to resuscitate a patient after a presumed bupivacaine-related cardiac arrest. The Journal of the American Society of Anesthesiologists, 2006. 105(1): p. 217-218.
3. Litz, R., et al., Successful resuscitation of a patient with ropivacaine‐induced asystole after axillary plexus block using lipid infusion. Anaesthesia, 2006. 61(8): p. 800-801.
4. Forsberg, M., et al., No support for lipid rescue in oral poisoning: A systematic review and analysis of 160 published cases. Human & Experimental Toxicology, 2017. 36(5): p. 461-466.
5. Smolinske, S., et al., Utilization of lipid emulsion therapy in fatal overdose cases: an observational study. Clinical Toxicology, 2019. 57(3): p. 197-202.
6. Türkdoğan, A.K., et al., Lipid Emulsion Therapy in Lipophilic or Hydrophilic Drug Intoxication: The Last Weapon in Our Arsenal. Eurasian Journal of Emergency Medicine, 2019. 18(2): p. 90-94.
7. Gitman, M. and M.J. Barrington, Local anesthetic systemic toxicity: a review of recent case reports and registries. Regional anesthesia & pain medicine, 2018. 43(2): p. 124-130.
8. Basiouny, S., et al., Intravenous lipid emulsion as an adjuvant therapy of acute antipsychotic poisoning: a randomized controlled trial. Ain Shams Journal of Forensic Medicine and Clinical Toxicology, 2022. 38(1): p. 19-32.
9. Mithani, S., et al., A cohort study of unstable overdose patients treated with intravenous lipid emulsion therapy. Canadian Journal of Emergency Medicine, 2017. 19(4): p. 256-264.
10. Cave, G., et al., LIPAEMIC report: results of clinical use of intravenous lipid emulsion in drug toxicity reported to an online lipid registry. Journal of Medical Toxicology, 2014. 10: p. 133-142.