EFFICIENCY APPLICATION OF HOUR-1 BUNDLE IN THE TREATMENT OF PATIENTS WITH SEPTIC SHOCK AT NATIONAL HOSPITAL FOR TROPICAL DISEASES

Đình Phú Vũ , Mạnh Hùng Thân , Bá Tỏa Đặng

Main Article Content

Abstract

Septic shock is a multi-organ failure, hypotension leading to tissue hypoperfusion with a high mortality rate if not treated promptly. Objectives: To analyze the effectiveness of the application of a hour -1 bundle in patients with septic shock. Methods: Prospective analysis, comparing treatment results on 2 groups of septic shock patients with and without the hour - 1 bundle. Results: Septic shock is a serious disease, the mortality rate in our study is still high (60.2%), the main entrance is from the gastrointestinal tract (36.7%), male accounts for mainly (71.4%). The rate of complete application of the hour - 1 bundle of initial septic shock resuscitation on patients was high at 77.6%, the most common measure was blood culture before antibiotics (100.0%), low especially fluid resuscitation of at least 30 ml/kg in the first hour (68.0%). The mortality rate at hospital discharge was 60.2%, of which the mortality rate in the group that completed the 1-hour package was 54.0%, which was 81.8% lower than that in the group that did not complete the hour - 1 bundle. Conclusion: 1-hour early resuscitation package is effective in reducing mortality in patients with septic shock.

Article Details

References

1. Umemura, Y., T. Abe, H. Ogura, et al., (2022). Hour-1 bundle adherence was associated with reduction of in-hospital mortality among patients with sepsis in Japan. PLOS ONE, 17(2), e0263936.
2. Nguyễn Hữu Luân and Trần Thị Kim Uyên, (2021). Tỷ lệ hoàn thành gói hồi sức trong giờ đầu và các kết cục liên quan ở trẻ sốc nhiễm khuẩn. . Y học Thành phố Hồ Chí Minh.
3. Trần Văn Quý, (2019). Nghiên cứu một số yếu tố tiên lượng tử vong ở người bệnh sốc nhiễm khuẩn điều trị tại bệnh viện bệnh nhiệt đới trung ương. Luận văn Thạc sĩ Y học. Đại học Y Hà Nội;.
4. Giang, B.T.H., (2016). Nghiên cứu một số thông số huyết động và chức năng tâm thu thất trái ở người bệnh sốc nhiễm khuẩn. Luận văn Tiến sĩ Y học. Đại học Y Hà Nội; .
5. Zhou, X., N. Zeng, P. Liu, et al., (2021). Sex Differences in In-hospital Mortality of Patients With Septic Shock: An Observational Study Based on Data Analysis From a Cover Sheet of Medical Records in Beijing. Frontiers in Medicine, 8, 733410.
6. De Backer, D., J. Creteur, M.-J. Dubois, et al., (2006). The effects of dobutamine on microcirculatory alterations in patients with septic shock are independent of its systemic effects. Critical care medicine, 34(2), 403-408.
7. Beck, V., D. Château, G. Bryson, et al., (2014). Timing of vasopressor initiation and mortality in septic shock: A cohort study. Critical care (London, England), 18, R97.
8. Hellman, T., P. Uusalo, and M. Järvisalo, (2021). Renal Replacement Techniques in Septic Shock. International Journal of Molecular Sciences, 22.