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THE ASSOCIATION BETWEEN CHIMERISM RESULTS AND SOME COMPLICATIONS AFTER ALLOGENEIC STEM CELL TRANSPLANTATION FOR TREATMENT OF SOME HEMATOLOGICAL DISEASES AT NATIONAL INSTITUTE OF HEMATOLOGY AND BLOOD TRANSFUSION DURING PERIOD 2010-2021
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Abstract
Evaluation of graft transformation from patients’ cell to donors (chimerism) is very important in monitoring transplantation outcomes. Objective: To explore the association between chimerism results and some complications after allogeneic stem cell transplantation for treatment of some hematological diseases at National Institute of Hematology and Blood transfusion from 2010-2021. Subjects: 218 patients with benign and malignant blood diseases, treated by allogeneic stem cell transplantation at Stem cell transplantation department. Phương pháp nghiên cứu: Analytical retrospective and prospective study. Results: 170 patients achieved complete chimerism, 19 patients had mixed chimerism while 29 patients had primary graft failure. Patients with complete chimerism had significantly better overall and event-free survival compared to other groups, but these had higher risk of chronic GvHD. Decreasing of chimerism in any time after transplantation was related to higher risk of mortality for patients. Conclusion: chimerism evaluation has a very important role in monitoring post-transplant outcomes which may help to indicate appropriate treatment.
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References
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