Article Sidebar
Views PDF: 73
THE ASSOCIATION BETWEEN CHIMERISM RESULTS AND SOME COMPLICATIONS AFTER ALLOGENEIC STEM CELL TRANSPLANTATION FOR TREATMENT OF SOME HEMATOLOGICAL DISEASES AT NATIONAL INSTITUTE OF HEMATOLOGY AND BLOOD TRANSFUSION DURING PERIOD 2010-2021
Main Article Content
Abstract
Evaluation of graft transformation from patients’ cell to donors (chimerism) is very important in monitoring transplantation outcomes. Objective: To explore the association between chimerism results and some complications after allogeneic stem cell transplantation for treatment of some hematological diseases at National Institute of Hematology and Blood transfusion from 2010-2021. Subjects: 218 patients with benign and malignant blood diseases, treated by allogeneic stem cell transplantation at Stem cell transplantation department. Phương pháp nghiên cứu: Analytical retrospective and prospective study. Results: 170 patients achieved complete chimerism, 19 patients had mixed chimerism while 29 patients had primary graft failure. Patients with complete chimerism had significantly better overall and event-free survival compared to other groups, but these had higher risk of chronic GvHD. Decreasing of chimerism in any time after transplantation was related to higher risk of mortality for patients. Conclusion: chimerism evaluation has a very important role in monitoring post-transplant outcomes which may help to indicate appropriate treatment.
Article Details
References
2. H Joachim Deeg, Rachel B Salit, Tim Monahan, et al. (2020). Early Mixed Lymphoid Donor/Host Chimerism is Associated with Improved Transplant Outcome in Patients with Primary or Secondary Myelofibrosis. Biol Blood Marrow Transplant, 26, 2197-2203.
3. Seyed Asadollah Mousavi, Mina Javadimoghadam, Ardeshir Ghavamzadeh, et al. (2017). The Relationship between STR-PCR Chimerism Analysis and Chronic GvHD Following Hematopoietic Stem Cell Transplantation. Int J Hematol Oncol Stem Cell Res, 11, 24-9.
4. Bungo Saito, Takahiro Fukuda, Hiroki Yokoyama, et al. (2008). Impact of T Cell Chimerism on Clinical Outcome in 117 Patients Who Underwent Allogeneic Stem Cell Transplantation with a Busulfan-Containing Reduced-Intensity Conditioning Regimen. Biol Blood Marrow Transplant 14, 1148-55.
5. Monika Lejman, Agnieszka Zaucha-Prażmo, Joanna Zawitkowska, et al. (2019). Impact of early chimerism status on clinical outcome in children with acute lymphoblastic leukaemia after haematopoietic stem cell transplantation. BMC Cancer, 19, 1-8.
6. Ran Reshef, Elizabeth O. Hexner, Alison W. Loren, et al. (2014). Early Donor Chimerism Levels Predict Relapse and Survival after Allogeneic Stem Cell Transplantation with Reduced-Intensity Conditioning. Biol Blood Marrow Transplant 20, 1758-66.