HIỆU QUẢ CHỐNG DÍNH CỦA HYALURONIC ACID TRONG PHẪU THUẬT NỘI SOI MŨI XOANG: TỔNG QUAN LUẬN ĐIỂM VÀ PHÂN TÍCH GỘP

Abstract

Objective: Evaluate the anti-adhesive effect of using hyaluronic acid in endoscopic sinus surgery. Methods: A scoping review including studies using hyaluronic acid after endoscopic sinus surgery on patients with chronic rhinosinusitis was performed. A meta-analysis was performed on adhesion event frequency. Other parameters included other subjective endoscopic findings and objective outcomes. Results: 10 studies including 483 patients met the selection criteria. A meta-analysis of adhesion formation frequency on endoscopy demonstrated a lower odds ratio in the hyaluronic acid intervention group of 0.45 (95 percent confidence interval = 0.30 – 0.68). Hyaluronic acid use was not assocated with any significant adverse events. Conclusion: Hyaluronic acid appears to be clinically safe and well tolerated in studies, and can be used as an adjunct after endoscopic sinus surgery to limit adhesion rate. To expect more accurate results, further reseaches including stricter study selection criteria, randomized controlled studies with larger number of patients are needed.