TÌNH TRẠNG TỔN THƯƠNG THẬN CẤP Ở BỆNH NHÂN NGỘ ĐỘC CẤP DIQUAT

Abstract

Objective: to describe the severity and progress of acute renal failure – acute kidney injury (AKI) in patients with acute diquat poisoning. Methods: the study included 114 patients with acute diquat poisoning treated at Poison Control Center of Bach Mai Hospital from July 2022 to July 2023. Results: Acute kidney injury in patients with acute Diquat poisoning was 38,6% at admission and during treatment was 76,3% (87 patients). Grade of AKI: grades 1, 2, 3 account for 12,6%; 13,8%; 73,6%. In the group of patients with acute kidney injury, 69% were anuric. Clinical characteristics of Diquat poisoning patients with AKI: gastrointestinal disorders (vomiting, sore throat, abdominal pain, diarrhea) 89,6%, mouth ulcers 57,5%, respiratory failure with ventilation 72,4%, consciousness disorder 54%, convulsions 28,7%; Oliguria - anuria 72,0%. Paraclinical characteristics: WBC 23.88, metabolic acidosis with increased anion gap, acute liver injury, rhabdomyolysis, increased lactate. The more severe the poisoning level, the higher the rate of kidney failure and the severity of kidney damage, p<0.01. The mortality rate in patients with diquat poisoning and kidney damage was 74.7%. Conclusions: the AKI rate in patients with acute diquat poisoning at the Poison Control Center of Bach Mai Hospital was 76,3%. Reported dosage, blood diquat concentration were associated with AKI. Mortality increased in patients have AKI.