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Date Published: 05/02/2024
Abstract Views: 473
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DOI: https://doi.org/10.51298/vmj.v535i1.8592
Issue
Vol. 535 No. 1 (2024)
Section
Các bài báo
How to Cite
Mai , T. C. ., Trần , H. T. ., Nguyễn , Đăng H. ., Võ , K. N. ., & Bùi , T. P. . (2024). INHIBITORY ACTIVITY OF ANGIOTENSIN I-CONVERTING ENZYME AND HYPERGLYCEMIC ENZYMES (Α-AMYLASE AND Α-GLUCOSIDASE) FROM EXTRACT OF RHINACANTHUS NASUTUS LEAVES. Vietnam Medical Journal, 535(1). https://doi.org/10.51298/vmj.v535i1.8592

INHIBITORY ACTIVITY OF ANGIOTENSIN I-CONVERTING ENZYME AND HYPERGLYCEMIC ENZYMES (Α-AMYLASE AND Α-GLUCOSIDASE) FROM EXTRACT OF RHINACANTHUS NASUTUS LEAVES

Thành Chung Mai , Hữu Thạnh Trần , Đăng Hoành Nguyễn , Khôi Nguyên Võ , Thanh Phong Bùi

Main Article Content

Abstract

Objective: Currently, inhibiting enzymes such as angiotensin-converting enzyme (ACE), α-glucosidase, α-amylase to limit hypertension (hypertension) and diabetes mellitus (DM) is considered a popular trend. Subjects and methods: This study was carried out with the aim of evaluating the enzyme inhibition ability of total extract (TP) and fractionated extract of diethyl ether (EE), chloroform (CF), n-butanol (BU), and water (WA) from Rhinacanthus nasutus leaves at in vitro level. Results: The highest inhibitory effect was in the chloroform fractions of the enzymes ACE, α-amylase, α-glucosidase with IC50 values of 6.81; 280.05; 72.76 μg/ml. Conclusion: Rhinacanthus nasutus leaf extract can be used to support the treatment of hypertension and type 2 diabetes.

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References

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