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SERUM CONCENTRATION OF TNF-ALPHA AMONG PATIENTS WITH CHRONIC SPONTANEOUS URTICARIA
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Abstract
Background: Chronic spontaneous urticaria is a common skin disorder with high recurrent rate. The disease’s pathogenesis is closely related to the release of histamine and vascular activating chemical mediators from mast cells. Besides, many studies show that cytokines play an essential role in the pathogenesis. Tumor necrosis factor - alpha (TNF-alpha) is a proinflammatory cytokine intimately involved in inflammatory, immune, and pruritic response. Objective: Our research aimed to determine clinical characteristics, epidemiology and level of TNF-alpha serum concentration in patients with chronic spontaneous urticaria at University Medical Center of Ho Chi Minh city. Methods: 60 chronic spontaneous urticaria patients (age ≥18) was recruited. 30 healthy adults served as the control group. UAS7 of chronic urticaria patients was evaluated during the interview. Serum TNF-alpha was measured using Avi Bion Human TNF-alpha. Results: 60 patients with chronic spontaneous urticaria (18 men and 42 women) had median age at 35.8 ± 10.4 years. The serum concentration of TNF-alpha in the group of chronic spontaneous urticaria patients was significantly higher than that of the healthy group (p=0.0002). Conclusion: Serum TNF-alpha was significantly rose in chronic spontaneous urticaria patients. Therefore, our finding suggests that TNF-alpha holds the key in chronic spontaneous urticaria pathogenesis and serum TNF-alpha could be used as a clinical marker of severity in this condition.
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References
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