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Date Published: 07/08/2021
Abstract Views: 569
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DOI: https://doi.org/10.51298/vmj.v504i1.870
Issue
Vol. 504 No. 1 (2021)
Section
Các bài báo
How to Cite
Bích Ngọc, T. ., Gia Tuyển, Đỗ ., & Gia Bình, N. . (2021). THE OUTCOME OF CONCURRENT TREATMENT WITH 6-MONTH HIGH DOSE INTRAVENOUS ENDOXAN AND PLASMA EXCHANGE FOR LUPUS NEPHRITIS FLARE IN NEPHRO-UROLOGY DEPARTMENT, BACH MAI HOSPITAL. Vietnam Medical Journal, 504(1). https://doi.org/10.51298/vmj.v504i1.870

THE OUTCOME OF CONCURRENT TREATMENT WITH 6-MONTH HIGH DOSE INTRAVENOUS ENDOXAN AND PLASMA EXCHANGE FOR LUPUS NEPHRITIS FLARE IN NEPHRO-UROLOGY DEPARTMENT, BACH MAI HOSPITAL

Trần Bích Ngọc1,, Đỗ Gia Tuyển1,2, Nguyễn Gia Bình3
1 Urology-Nephrology and Dialysis Center, Bach Mai Hospital
2 Hanoi Medical University
3 Bach Mai Hospital

Main Article Content

Abstract

Objectives: evaluate the change in clinical, laboratory in patients with lupus nephritis flare to concurrent treatment with plasma exchange and high dose intravenous endoxan. Participants: 55 patients with lupus nephritis flare were given treatment from October 2014 to June 2018 in Bach mai Hospital. The standard regimen includes 3 sessions of plasma exchange, followed by monthly intravenous endoxan (500mg/m2 BSA) for 6 months in combination with prolonged steroid. Methods: prospective study Outcomes: After 6 months, mean SLEDAI score decreased from 24.1±5.5 to 11.5±6.1 (p < 0.00001). Serum anti ds-DNA antibodies level decreased from 163.9±131.8 IU/mL to 75.3±76.1 IU/mL (p =0.005). Mean eGFR increased from 27.6±20.6 to 67.6±37.7 ml/min/1.73m2. Complete renal response was 10.9%, partial renal response 49.1%. Conclusions: This treatment was efficient, safe and could be appropriate to apply in Vietnam.

Article Details

Keywords

lupus nephritis, plasma exchange, cyclosphosphamid

References

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