NGHIÊN CỨU TÁC DỤNG GIẢM XƠ VỮA ĐỘNG MẠCH CỦA CHẾ PHẨM SAGYDI (SAD) TRÊN ĐỘNG VẬT THỰC NGHIỆM

Abstract

The study was conducted on laboratory-bred rabbits, and data were collected over an 8-week period. The rabbits were divided into 5 groups to establish an atherosclerosis model. The groups were treated with distilled water, a mixture of cholesterol oil, atorvastatin, and SAD at different doses. Evaluation parameters included blood lipid levels and assessments of the atherosclerotic condition of the main arteries and hepatic fat accumulation through macroscopic and microscopic examinations. The results demonstrated that SAD at doses of 0.18g dried high powder/kg/day and 0.54g dried high powder/kg/day exhibited anti-atherosclerotic effects, reduced blood lipid levels, and improved histopathological images of the main arteries and rabbit liver compared to the model group. This opens up prospects for the potential application of SAD in the treatment and prevention of issues related to atherosclerosis.