NỒNG ĐỘ MALONDIALDEHYDE TRONG BAO RĂNG, MÔ NƯỚU VÀ NƯỚC BỌT Ở BỆNH NHÂN CÓ RĂNG KHÔN HÀM DƯỚI LỆCH NGẦM KHÔNG TRIỆU CHỨNG

Abstract

Purpose: Reactive oxygen species create oxidate stress and tissue damage. Malondialdehyde (MDA) is main endproducts of lipid peroxidation that increases with oxidative stress. The purpose of our study is to evaluate oxidative stress in dental follicles (DFs) of radiologically asymptomatic mandibular impacted third molars (MITM) using MDA and analyzing the correlation between concentrations in saliva and in DFs. Material and method: 24 patients with one asymptomatic MITM had DF widths on panoramic radiographs equal or narrower than 2,5 mm were included in the study and 24 healthy gingival tissues in the same patients were obtained as a control group. Saliva samples were also collected from all subjects. All samples were analyzed for MDA. Results: Concentration of MDA were considerably higher in DFs than those from healthy gingival tissues of same patient (p<0,05). However, salivary MDA showed no correlation with levels in DFs (p=0,24). Conclusion: Significant oxidate stress may occur in DFs of asymptomatic MITMs. From initial findings of this study, subsequent investigations and comprehensive studies are required to determine the role of antioxidants that neutralize free radicals in DFs.