BIỂU HIỆN Ki-67 TRONG UNG THƯ TUYẾN NƯỚC BỌT

Abstract

Introduction: Increased Ki-67 expression is associated with the pathology, malignancy, and poor prognosis of salivary gland cancer. This study investigates the relationship between the Ki-67 expression and clinical and pathological characteristics of salivary gland cancer. Subjects and methods: A cross-sectional descriptive study of 111 cases of salivary gland cancer treated at the Ho Chi Minh City Oncology Hospital from January 1, 2016, to December 31, 2017. Results: Ki-67 expression was higher in females than males (median 3.7% vs 3.3%). Ki 67 expression was different according to age group, specifically the rate was higher in the age group of 40 years and over (median 4.2% in the 40-59 age group and 7.3% in the ≥60 age group). Ki-67 expression in major salivary gland cancer was higher than in minor salivary gland cancer. T1 and T2 tumors had lower Ki-67 expression (3.1% and 2.3%) than T3 and T4 tumors (3.6% and 5.7%). Tumors with distant metastasis had much higher Ki-67 expression than tumors without metastasis (26.5% and 3.4%). The cases with lymph node metastasis (N1 and N2) had significantly higher Ki-67 expression than those without positive lymph nodes (17.9% and 13.8% vs 2.8%); the difference was statistically significant (p < 0.05). In addition, tumors in stage IV had higher Ki-67 expression (5.8%) than those in stage I (3.1%), stage II (2.1%), and III (2.3%). Regarding histological classification, the group with high Ki-67 expression was adenoid cystic carcinoma, mucoepidermoid carcinoma, and a single case of carcinoma ex pleomorphic adenoma with an expression rate of up to 67%. Conclusion: Ki-67 expression may reflect the degree of clinical progression, the degree of pathological malignancy, and the prognosis of salivary gland cancer.