ĐẶC ĐIỂM LÂM SÀNG, GIẢI PHẪU BỆNH VÀ DI CĂN HẠCH GIẢI PHẪU BỆNH CỦA UNG THƯ TẾ BÀO GAI HỐC MIỆNG

Abstract

Objective: To identify the clinicopathological features of oral cavity squamous cell carcinomas (OSCCs) and investigate association between lymph node metastasis and clinicopathological parameters in  oral cavity squamous cell carcinoma (OSCC).  Methods: A cross-sectional descriptive and analytical study was conducted. A sample of 157 patients with primary OSCC was examined, recording their clinical characteristics and histopathological features before and after surgery. Results: OSCC was more prevalent in males with a male-to-female ratio of 3,6:1. The distribution of cancer locations differed between males and females (p<0,001), with the tongue being the most common site in both genders. Most patients (73,9%) suffered diagnosis at late stages (III-IV). The rate of histopathological lymph node metastases was higher (56,3%) compared to the rate of clinical lymph node metastases (38.9%).  Histopathological lymph node metastasis is significantly associated with clinical lymph node metastases (p<0,001), histological grade (p<0,001), degree of keratinization (p=0,013), nuclear polymorphism (p=0,019), number of mitosis (p=0,017), pattern of invasion (p=0,006) and stage of invasion (p=0,043). Conclusion: Current preoperative diagnostic methods for lymph node metastasis cannot entirely detect all cases with microscopic involvement. Histological grade, nuclear polymorphism, pattern and stage of invasion may indicate the presence of histopathological lymph node involvement in OSCC.