ĐẶC ĐIỂM LÂM SÀNG, CẬN LÂM SÀNG Ở BỆNH NHÂN VIÊM GAN VIRUS B TỰ NGỪNG THUỐC TẠI BỆNH VIỆN BỆNH NHIỆT ĐỚI TRUNG ƯƠNG TỪ 2018 – 2023

Abstract

Chronic hepatitis B with NA treatment indication requires long-term monitoring and treatment, following the instructions. If a patient stops taking NA medication on his own, it can lead to a flare-up, which can be life-threatening for the patient. Objective: Describe clinical and paraclinical characteristics in patients with hepatitis B virus who self-discontinued medication at the National Hospital of Tropical Diseases from 2018 - 2023. Subjects and methods: descriptive study of a series of cases. Combining retrospective and prospective studies of 336 patients with hepatitis B virus who spontaneously discontinued NA medication. Results: Common symptoms of patients upon admission are mainly: fatigue (95.8%), loss of appetite (86.3%), jaundice and yellow eyes (71.4%), and urine. dark (60.7%). The platelet count (n= 314) was in the range of 157.82 ± 91.19. The prothrombin rate (n= 316) was in the range of 66.58 ± 23.43%. Increased total blood bilirubin concentration in the patient group (>17µmol/l) occurred in 79.5% of patients. Median total bilirubin value = 51.2. Nearly 70% of patients had AST values > 200 UI/L, 76.9% of patients had ALT values > 200 UI/L, 85.0% of patients had viral load at admission ≥ 104 copies/ml, 38.9% of patients had F4 index. The average value of the Meld-score index upon admission was 16.23 ± 8.32. Conclusion: It is necessary to advise patients more carefully about the NA drug treatment regimen and course.