DẤU HIỆU “ĐUÔI CHIM ÉN” TRÊN CỘNG HƯỞNG TỪ NÃO 3-TESLA TRONG CHẨN ĐOÁN BỆNH PARKINSON

Abstract

Background: Parkinson's disease is a common neurodegenerative disease but currently the diagnosis is mainly based on clinical criteria with certain accuracy. There are some imaging biomarkers that are being studied to increase diagnostic accuracy. Objective: To determine the sensitivity, specificity and predictive value of loss of the "swallow tail" sign on brain magnetic resonance imaging 3-Tesla in the diagnosis of Parkinson's disease. Methods: This is a case-control study with case group of 52 patients diagnosed with Parkinson's disease according to the criteria of the International Parkinson's Disease and Movement Disorder Society; and the control group included 35 people without any symptom of Parkinsonism. The “swallow tail” sign on brain MRI - 3T - SWI was evaluated independently and blinded in clinical by two neuroradiologists. The validity of the "swallow tail" sign in diagnosing Parkinson's disease was analyzed on SPSS 20.0. Reliability between two neuroradiologists was assessed based on Cohen's kappa index (κ). Significance level with p value <0.05. Results: Loss of the "swallow tail" sign unilaterally or bilaterally exists in all patients with Parkinson's disease and only in 2 cases (accounting for 5.71%) in the control group. The reliability between two neuroradiologists with Cohen's kappa index was 0.634 - 0.739. Loss of the "swallow tail" sign has a sensitivity and specificity of 94.34% and 91.67%, respectively. Conclusion: Loss of the "swallow tail" sign has high value in the diagnosis of Parkinson's disease and has the potential to become a new tool supporting in diagnosing Parkinson's disease.