XU HƯỚNG ĐỀ KHÁNG KHÁNG SINH CỦA CHỦNG VI KHUẨN ACINOBACTER BAUMANII GÂY BỆNH TẠI BỆNH VIỆN NGUYỄN TRI PHƯƠNG: KHẢO SÁT TẠI PHÒNG XÉT NGHIỆM GIAI ĐOẠN 2020 - 2023

Abstract

Introduction: Antibiotic resistance of Gram-negative bacteria strains, especially Acinobacter baumanii is becoming increasingly serious in health care facilities. The understanding of antimicrobial resistance of A. baumanii supports the treatment of bacterial infections and the management of antibiotic used in hospitals. Objectives: To characterize the distribution and trend of antibiotic resistance in laboratories of pathogenic A. baumanii strains at Nguyen Tri Phuong Hospital in the period of 2020 – 2023. Subjects and methods: case-series study on 1496 specimens with A. baumanii strains isolated from patients treated at Nguyen Tri Phuong Hospital from January 2020 to December 2023. Differences in antibiotic resistance tendencies are examined using Chi squared test. Results: samples isolated from internal medicine departments accounted for 54.1%. The most abundant specimen was fluid from the lower respiratory tract (74.1%). After four years, A. baumanii was still completely susceptible to colistin, 42.2% resistant to doxycycline, the rest of the antibiotics had very high resistance rates, from 70% to over 90%. The trend of antibiotic resistance of A. baumanii increased statistically significant (p < 0.05) with 9/14 antibiotics tested. Trend of antibiotic resistance in each clinical department group is similar to the model of the whole hospital, in which the ICU has the highest resistance rate. Conclusions: A. baumanii is also 100% sensitive to Colistin, but very resistant to most antibiotics tested and the trend increases year by year. ICU has the highest rate of resistance among departments.