BỆNH U MÔ BÀO X: NHÂN 3 TRƯỜNG HỢP BIỂU HIỆN BỆNH Ở XƯƠNG THÁI DƯƠNG

Abstract

Langerhans’ cell histiocytosis (LCHs) or histiocytosis X is a rare disease characterized by an abnormal proliferation of histiocytes. It is generally known as eosinophilic granuloma (EG), Hand-Schuller-Christian (HSC) disease and Letterer-Siwe (LS) disease which vary in the prognostic result. The histiocytic lesions can occur in visceral organ(s) or bone(s) that can lead to presentation of the disease with different clinical manifestations including otologic manifestations. The presence of otorrhea or aty-pical otitis media, granulation tissue, aural polyps, or a postauricular mass, temporal CT scanner showed a large soft tissue mass in the mastoid region, extensive destruction of mastoid bone should alert the otolaryngologist to the possibility of LCH. We report three cases of otologic histiocytosis with the temporal bone involvement which mimics as an acute mastoiditis c/o retroauricular exteriorization. A computed tomography scan describe the extent of the temporal bone involvement. A definitive diagnosis of histocytosis was histopathology and immunohistochemical detection of CD-1a and S-100 antigen in the tissue samples. The management of temporal bone LCH include surgery, radiotherapy, chemotherapy and steroids therapy.