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CORNEAL ENDOTHELIAL CELLS CHANGES 6 MONTHS FOLLOWING CATARACT SURGERY IN PATIENTS WITH PSEUDOEXFOLIATION SYNDROME
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Abstract
Purpose: To investigate corneal endothelial cells alterations after cataract sugery in patients with pseudoexfoliation syndrome (PEX). Methods: Prospective case-control study. 70 eyes separated into two groups: 35 eyes with PEX and 35 eyes without PEX, which indicated phacoemulsification surgery from January 2023 to June 2023 in Ho Chi Minh City Eye hospital. Every patients were done cataract surgery with Alcon Centurion phaco machine. Preoperative and after 1-week, 1-month, 3-month and 6-month post-operative endothelial cell density were mesured with NIDEK CEM 530 specular microscopy. Surgical parameters were recorded after the surgery (Phacotime, CDE, FP3, fluid and pupil diameter). Results: The average age of PEX patients was 72,14 ± 8,49. This syndrome was common in female population. There were no statistically difference of anterior chamber depth, cataract grading, pre-operative visual acuity and intraocular pressure between two groups. Phacotime, FP3, CDE were higher and pupil diameter was significantly smaller in PEX group. ECD before surgery was similar between PEX and control. Postoperative ECD at 1 week, 1 month, 3 months, and 6 months was lower in the PEX group than in the control group. Visual acuity improved less at 6 months after surgery in the PEX group than in the group that did not show the syndrome. Phaco time and phaco energy (CDE and FP3) were recorded to correlate with the degree of corneal endothelial cell damage 6 months after phaco surgery. Conclusion: PEX is a age-related syndrome, that appears in older patients. Phaco surgery is currently a safe and effective method to improve patients’ vision. Endothelial cell density in the group of PEX eyes decrease more after phaco surgery than control eyes. PEX needs to be examined and detected carefully, especially in the elderly patient group. Phaco surgery in this group of PEX patients should be performed by an experienced surgeon. At 6 month period post-operative ECD and visual acuity are lower in PEX patients.
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Keywords
Pseudoexfoliation, phacoemulsification, endothelial cell density
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