HOẠT ĐỘ ENZYM AST, ALT Ở BỆNH NHÂN SỐT XUẤT HUYẾT DENGUE

Abstract

Background: Dengue fever is an acute infectious disease caused by the Dengue virus, with the Aedes aegypti mosquito serving as the disease vector. Hepatic dysfunction is a significant characteristic observed in Dengue virus infections. Its impact on the liver often lacks symptoms but can vary in severity. The elevation of transaminase activity without symptoms of acute liver failure, with varying other manifestations, presents a significant challenge for treating physicians. Objectives: Surveying the changes in AST, ALT activity, and clinical characteristics in dengue hemorrhagic fever patients at Le Van Thinh Hospital in 2022. Methods: Retrospective study of patients aged 18 years and older, diagnosed with dengue fever according to the standards of the Ministry of Health in 2019. Results: Among a total of 142 patients, there are 108 cases of dengue hemorrhagic fever, 34 cases of dengue fever with basic symptoms, and no cases of severe dengue hemorrhagic fever. Gender distribution showed that 58 (40.8%) patients were male, and 84 (59.2%) were female. Clinical features included gastrointestinal symptoms (54.9%), muscle pain (32.4%), and subcutaneous hemorrhage (21.1%). Clinical laboratory findings revealed that 85.9% of patients had elevated AST (Aspartate Aminotransferase), and 64.7% had elevated ALT (Alanine Aminotransferase). AST exhibited a more significant and frequent increase compared to ALT. The degree of AST and ALT elevation primarily ranged from 1 to 3 times the normal levels. The increase in AST by 1 to 3 times the normal levels was more common in the NAFLD group. Conclusion: AST and ALT enzyme activities change in dengue hemorrhagic fever. Regularly screen liver enzymes in Dengue Fever patients to detect early liver damage, aiding in timely assessment and treatment