NGHIÊN CỨU TÌNH TRẠNG ĐỀ KHÁNG INSULIN TRÊN BỆNH NHÂN TIỀN ĐÁI THÁO ĐƯỜNG BẰNG MÔ HÌNH HOMA2 TẠI BỆNH VIỆN CHỢ RẪY

Abstract

Background: Prediabetes is a health condition between normality and type 2 diabetes. The pathogenesis is based on insulin resistance. This study was conducted to analyze insulin resistance in prediabetic subjects. Objective: To determine the prevalence of insulin resistance according to the HOMA2 model in the prediabetic group, compared with the non-prediabetic control group. Subjects and Methods: The cross-sectional study collected data of 156 prediabetic and 152 non-prediabetic people from February 2023 to September 2023 at the Cho Ray Hospital Examination Department. Insulin resistance was determined using the HOMA2 model, the cut-off threshold being the 75^th value of the control group. Prediabetes was diagnosed according to ADA 2022 standards. Results: The number of subjects selected to analyze was 144 people with prediabetes and 122 people without prediabetes. The prevalence of insulin resistance in the prediabetic group was 55.6%, which was statistically significant different from the non-prediabetic group of 24.6%. The HOMA2-IR (Median [IQR]) value in the prediabetes group was 1.40 (0.92 – 2.07), which was statistically significant higher than in the non-preiabetic group of 0.94 (0.60 – 1.29), P < 0.001. Conclusions: The prevalence of insulin resistance in people with diabetes was 55.6%, statistically significant greater than in the non-diabetic group of 24.6%, P < 0.001