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Date Published: 21/08/2021
Abstract Views: 380
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DOI: https://doi.org/10.51298/vmj.v504i2.906
Issue
Vol. 504 No. 2 (2021)
Section
Các bài báo
How to Cite
Thị Huyền, P. . (2021). DISEASE FREE SURVIVAL AND ASSOCIATED FACTORS OF ADJUVANT CHEMOTHERAPY DOCETAXEL AND CYCLOPHOSPHAMID (TC) REGIMEN IN ELDERLY BREAST CANCER PATIENTS. Vietnam Medical Journal, 504(2). https://doi.org/10.51298/vmj.v504i2.906

DISEASE FREE SURVIVAL AND ASSOCIATED FACTORS OF ADJUVANT CHEMOTHERAPY DOCETAXEL AND CYCLOPHOSPHAMID (TC) REGIMEN IN ELDERLY BREAST CANCER PATIENTS

Phùng Thị Huyền1,
1 Tân Triều Brach of National Cancer Hospital

Main Article Content

Abstract

Aims:  Our study aimed to evaluate disease free survival and associated factorsof adjuvant chemotherapy Docetaxel and Cyclophosphamid (TC) regimen  in elderly breast cancer patients  treated at K hospital. Population: 70 patients were women, ages ≥ 60, diagnosed breast cancer, treated by surgery mastectomy and adjuvant Docetaxel- Cyclophosphamid regimen at K hospital from 01/2013-12/2018. Methods: Retrospective description. Results: The mean age was 64.74 ± 3.94 (range 60 to 74, 67,1% had cardiovascular disease. 3-year and 5-year disease free survival were 87.7% and 81.1% respectively. DFS was associated with stage and molecular subtype (p<0.05). DFS was not significantly different between those with and without cardiovascular disease (p>0.05). Conclusion: Treatment adjuvant chemotherapy TC regimen in elderly patients has a high DFS rate and should be considered in clinical practice, especially for patients with cardiovascular disease.

Article Details

Keywords

Breast cancer, elderly, adjuvant chemotherapy, Docetaxel, Cyclophosphamid

References

1. Trần Văn Thuấn (2011), Điều trị nội khoa bệnh ung thư vú, Nhà xuất bản Y học, Hà Nội., .
2. Bùi Diệu (2011), Một số bệnh ung thư ở phụ nữ, Nhà xuất bản Y học, Hà Nội., .
3. DeSantis C.E., Fedewa S.A., Sauer A.G., et al. (2016). Breast cancer statistics, 2015: Convergence of incidence rates between black and white women. CA: A Cancer Journal for Clinicians, 66(1), 31–42.
4. Hoi L.V., Chuc N.T., and Lindholm L. (2010). Health-related quality of life, and its determinants, among older people in rural Vietnam. BMC Public Health, 10, 549.
5. Smith L.A., Cornelius V.R., Plummer C.J., et al. (2010). Cardiotoxicity of anthracycline agents for the treatment of cancer: Systematic review and meta-analysis of randomised controlled trials. BMC Cancer, 10(1), 337.
6. Muss H.B., Polley M.-Y.C., Berry D.A., et al. (2019). Randomized Trial of Standard Adjuvant Chemotherapy Regimens Versus Capecitabine in Older Women With Early Breast Cancer: 10-Year Update of the CALGB 49907 Trial. J Clin Oncol, 37(26), 2338–2348.
7. Mwangi J., Kulane A., and Van Hoi L. (2015). Chronic diseases among the elderly in a rural Vietnam: prevalence, associated socio-demographic factors and healthcare expenditures. Int J Equity Health, 14.
8. Lê Thị Sương (2014). Đánh giá kết quả điều trị bổ trợ ung thư vú giai đoạn II-IIIA bằng phác đồ 4AC- 4D.Trường Đại học Y Hà Nội.
9. Jones S., Holmes F.A., O’Shaughnessy J., et al. (2009). Docetaxel With Cyclophosphamide Is Associated With an Overall Survival Benefit Compared With Doxorubicin and Cyclophosphamide: 7-Year Follow-Up of US Oncology Research Trial 9735. JCO, 27(8), 1177–1183.