MỨC ĐỘ ĐỀ KHÁNG VỚI THUỐC KHÁNG NẤM CỦA CANDIDA SP PHÂN LẬP TỪ ĐƯỜNG HÔ HẤP BỆNH NHÂN TẠI BỆNH VIỆN ĐA KHOA THÀNH PHỐ CẦN THƠ

Abstract

Background: Diseases caused by Candida species cause lung disease, increasing the likelihood of complications and increasing hospital stay. Objectives: Evaluating the level of drug resistance of Candida sp isolated from the respiratory tract of patients at Can Tho city general hospital. Materials and methods: Cross-sectional descriptive study on a total of 127 specimens isolated from respiratory diseases at Can Tho City General Hospital, 2019-2023. Results: The identification results recorded that 4 Candida sp species were isolated, of which Candida albicans accounted for the highest proportion (70.1%), the lowest was Candida glabrata (0.8%); Candida sp was highly sensitive to Amphotericin B (93.7%), Voriconazole (92.1%), Micafungin (85%) and Fluconazole (78.7%); Strong resistance to Caspofungin (33.1%), Flucytosine (23.6%); Relatively high levels of intermediate resistance were Fluconazole (11%) and Flucytosine (16.5%). Except for Amphotericin B (p = 0.321) and Flucytosine (p = 1), the remaining antifungal drugs all had statistically significant differences between the two groups C. albicans and C. non albicans. Conclusions: Except for Caspofungin and Flucytosine, the remaining antifungal drugs have very high sensitivity (>78%) against Candida sp