KHẢO SÁT KHẢ NĂNG GẮN SẮT TOÀN PHẦN TRONG HUYẾT TƯƠNG Ở BỆNH NHÂN BỆNH THẬN MẠN TÍNH GIAI ĐOẠN CUỐI LỌC MÁU CHU KỲ

Abstract

Objectives: To evaluate the serum total iron binding capacity (TIBC) and its relation with some clinical and subclinical indicators in patients on maintenance hemodialysis (HD). Subjects and methods: A cross-sectional, descriptive study on 117 patients on maintenance hemodialysis and 57 healthy controls matched for age and gender at 103 Military Hospital from January, 2022 to December, 2023. All of the above people had done measurement serum TIBC by ELISA method. Results: the average value of serum TIBC in study group 53,38 (21,69 – 81,8) (µmol/l) was significantly lower than control group 70,17 (41,47 – 87,18) (µmol/l), p < 0,05. There was 6,8 % of patients who decreased the concentration of TIBC compared to the control group. The TIBC concentration was positively and significantly correlated with protein (r=0,2), serum iron (r=0,24), triglyceride (r = 0,283), p< 0,05. Meanwhile, there is a statistically significant negative correlation with age (r = -0,236), TSAT (r = -0,872), HDL-C (r = -0,182), p< 0,05. Conclusion: Plasma TIBC concentration is decreased in patients with end-stage chronic kidney disease on hemodialysis. Plasma TIBC concentration is positively related to protein, serum iron, triglyceride and negatively related to age, TSAT, HDL-C.