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Date Published:
10/04/2024
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Ngô, T. Q. M., & Trần, T. N. (2024). STUDY ON ANTI-α-GLUCOSIDASE OF CURCUMIN ISOLATED FROM CURCUMA LONGA RHIZOMES. Vietnam Medical Journal, 537(1B). https://doi.org/10.51298/vmj.v537i1B.9152
STUDY ON ANTI-α-GLUCOSIDASE OF CURCUMIN ISOLATED FROM CURCUMA LONGA RHIZOMES
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Abstract
The rhizome or yellow Turmeric root in Traditional Medicine is called Khuong Hoang. This medicinal herb is widely used in many Asian countries, including Vietnam, as a spice and medicine. The main active ingredients in Turmeric are diarylheptanoids, including curcumin. This study investigated the in vitro α-glucosidase inhibitory effect of curcumin. The results showed that curcumin has the ability to strongly inhibit α-glucosidase with IC50 7.73±0.62 µg/ml.
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References
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2. Feng, L.-P., et al., Two pairs of bisabolane sesquiterpenoid stereoisomers, bisacurone D-G, from the rhizome of Curcuma longa L. Fitoterapia (2020), 146: p. 104701.
3. Feng, Q., Chemical constituents of Curcuma longa I:bisabolane sesquiterpenes. Chinese Journal of Medicinal Chemistry (2007).
4. Tapsell, L.C., et al., Health benefits of herbs and spices: the past, the present, the future. Med J Aust (2006), 185(S4): p. S1-S24.
5. Hewlings, S.J. and D.S. Kalman, Curcumin: A Review of Its Effects on Human Health. Foods (2017), 6(10).
6. Khatun, M., et al., Assessment of the anti-oxidant, anti-inflammatory and anti-bacterial activities of different types of turmeric (Curcuma longa) powder in Bangladesh. Journal of Agriculture and Food Research (2021), 6: p. 100201.
7. Panda, V., et al., An Ayurvedic formulation of Emblica officinalis and Curcuma longa alleviates insulin resistance in diabetic rats: Involvement of curcuminoids and polyphenolics. Journal of Ayurveda and Integrative Medicine (2021), 12(3): p. 506-513.
8. Hakamata, W., et al., Design and screening strategies for alpha-glucosidase inhibitors based on enzymological information. Curr Top Med Chem (2009), 9(1): p. 3-12.
9. Lekshmi, P.C., et al., In vitro antidiabetic and inhibitory potential of turmeric (Curcuma longa L) rhizome against cellular and LDL oxidation and angiotensin converting enzyme. J Food Sci Technol (2014), 51(12): p. 3910-7.
10. Awin, T., et al., Identification of α-glucosidase inhibitory compounds from Curcuma mangga fractions. International Journal of Food Properties (2020), 23(1): p. 154-166.