ỨNG DỤNG TÁ DƯỢC ĐỒNG SẢN XUẤT TRONG BÀO CHẾ VIÊN PHÂN TÁN TRONG MIỆNG DÙNG CHO TRẺ EM CHỨA KHÁNG SINH CEFIXIM 100 MG

Abstract

Introduction: Cefixime is an orally third-generation cephalosporin antibiotic which exhibits a broad spectrum of activity against bacterial pathogens, especially for upper respiratory infections in pediatrics. This study aimed to apply an advanced co-processed excipient in the preparation of orodispersible tablet containing cefixime with rapid disintegration time and a desired dissolution rate. Methods: Orodispersible tablet was prepared by direct compression using CombiLac^® (Meggle). The tablet was evaluated regarding disintegrating time, in vitro dispersion time, wetting time, and water absorption ratio. HPLC method was employed for determination of cefixime in the research products. Results: Orodispersible tablets using co-processed excipient CombiLac (35%) and crospovidone (5%) had advantages in terms of disintegrating time (23,3s), in vitro dispersion time (30s) and wetting time (6s) compared to those that used others compositions. In addition, it also has the lowest friability level and at the same time reaches solubility according Vietnam Pharmacopoeia. The potential of CombiLac in improving mechanical strength concomitantly with disintegrating behaviour was clarified. Conclusion: The formulation of cefixime orodispersible tablets was successfully established. The achieved data could be a reference for pharmaceutical development in manufacturing sites in Vietnam