NHẬN XÉT TÍNH KHÁNG KHÁNG SINH CỦA STREPTOCOCCUS PNEUMONIAE GÂY NHIỄM KHUẨN HUYẾT Ở BỆNH NHI TẠI KHOA ĐIỀU TRỊ TÍCH CỰC NỘI KHOA, BỆNH VIỆN NHI TRUNG ƯƠNG

Abstract

Objective: To observe the antibiotic resistance of Streptococcus pneumoniae in pediatric patients with sepsis caused by S. pneumoniae. Subjects and methods: A retrospective descriptive study of a series of cases, including 46 pediatric patients from 1 month to 17 years old diagnosed with sepsis caused by S. pneumoniae treated at the Pediatric Intensive Care Unit, National Children Hospital, from January 2020 to August 2023. Results: patients with sepsis due to S. pneumoniae were infants (median age was 16 months). 44.8% of patients had one underlying disease (malnutrition, Down syndrome, thalassemia. For patients admitted with severe conditions, such as meningitis (43.5%), multiorgan failure (87%), and septic shock (58.7%), the morality of S. pneumoniae sepsis was very high (21.7%). Bacteria had a high rate of antibiotic resistance: the percentage of isolates sensitive to cefotaxime was 38.1%, and ceftriaxone was 34.9%. All of them were entirely resistant to clindamycin. There was a high rate of multidrug resistance: 65.2% (30/46). All isolates were sensitive to vancomycin, linezolid, and quinolones. Conclusion: S. pneumoniae has a high antibiotic resistance rate and is entirely vulnerable to vancomycin, linezolid, and quinolones.