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FACTORS AFFECTING USE OF VANCOMYCIN IN CHILDREN
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Abstract
Objectives: To investigate the factors affecting the safe and effective use of vancomycin in the treatment of severe infections in children. Methods: A descriptive cross-sectional study was conducted in pediatric patients who indicated vancomycin for more than 3 days. Trough vancomycin levels and creatinine clearance were measured to monitor the efficacy and safety of vancomycin use in these cases. Results: The study enrolled 40 cases. The average dose of vancomycin used was 55.83 ± 19.34 mg/kg/day. The median trough vancomycin concentration was 11.09 (7.84 – 16.46) μg/ml. The mean creatinine clearance was 80.18 ± 29.14 ml/min. Factors influencing the safe and effective use of vancomycin were vancomycin dose, way of vancomycin administration, and creatinine clearance. Conclusion: It is necessary to consider adjusting the dose of vancomycin, the way of vancomycin use according to creatinine clearance and trough vancomycin concentration to ensure safety and effectiveness in treatment
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Keywords
trough concentration; vancomycin; children.
References
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