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INVESTIGATION OF “NAO THONG LAC” FOR THE ACUTE AND SUBCHRONIC ORAL TOXICITY IN EXPERIMENTAL ANIMALS
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Abstract
The capsule of Nao thong lac processed from Bo duong hoan ngu prescription was used to evaluate the acute toxicity on white mice and sub-chronic toxicity in experimental rabbits. It was shown in the result that the dose of 60g/kg (equivalent to 12.5 times of clinical dose) had caused no acute toxicities. Regarding subchronic toxicity: the usage of doses 0.28 and 0.84g/kg in 4 weeks caused no effects on health condition and their hematopoietic function criteria; no changes were seen in the results of experiments evaluating liver function ALT, AST, total bilirubin, and protein) and kidney function (urea and creatinin).
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Keywords
Acute toxicity, subchronic toxicity; Nao thong lac.
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